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- 產(chǎn)品名稱： Anti Extracellular Death Factor mouse monoclonal antibody
- 產(chǎn)品貨號： CSMA10233Mo
- 貨期： 現(xiàn)貨
- 價格與訂購： 980
- 數(shù)量：
庫存： 100
- 規(guī)格： 50μg 100μg 200μg
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產(chǎn)品名（Product Name）
Anti Extracellular Death Factor mouse monoclonal antibody
貨號（Catalog No.）
CSMA10233Mo
種類（Category）
Primary antibody
宿主（Host）
Mouse
反應(yīng)種屬（Species specificity）
Escherichia coli
應(yīng)用實驗（Tested applications）
Elisa,IHC
克隆性（Clonality）
Monoclonal
克隆編號（Clone No.）
93-D-4
偶連物（Conjugation）
Unconjugate
免疫原（Immunogen）
NNWNN
別名
Description: mazEF is a toxin-antitoxin stress-induced module which is abundant on the chromosome of most bacteria including pathogens and most extensively studied in Escherichia coli. E. coli mazEF mediated cell death is a population phenomenon requiring the quorum-sensing (QS) ‘Extracellular Death Factor’ (EDF), the E. coli peptide NNWNN. Penta-peptide NNWNN (EcEDF) enhances the endoribonucleolytic activity of E. coli toxin MazF.The newly discovered extracellular death factor (EDF) is a pentapeptide with the sequence NNWNN in Escherichia coli. It was reported that it participated in the cell death process mediated by toxin-antitoxin system mazEF. Reactive oxygen species (ROS) are recently considered as common factors for bactericidal antibiotics-mediated cell death. Previous study indicated that EDF could scavenge hydroxyl radicals and might act as a signal molecule with dual effects, “death” and “survival”. But the structure-activity relationship of EDF and the effects of EDF on the activity of antibiotics remain unclear. In the present study, our results indicated that tryptophan could be the key residue to the hydroxyl radicals-scavenging activity of EDF, and EDF could protect Escherichia coli from killing by bactericidal antibiotics, but not by DNA-damaging or bacteriostatic antibiotics. Our results could provide novel evidence to understand the role of EDF in drug-resistance.
Uniprot ID
P0AC53
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Amily
