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- 產(chǎn)品名稱： SR8278
- 產(chǎn)品貨號(hào)： CS7837
- 貨期： 現(xiàn)貨
- 價(jià)格與訂購(gòu)： 960
- 數(shù)量：
庫(kù)存： 100
- 規(guī)格： 1mg 10mg 1g
- 產(chǎn)品信息
- 如何訂購(gòu)
產(chǎn)品描述
SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112
靶點(diǎn)活性
REV-ERBα
體外活性
SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells[1]
參考文獻(xiàn)
1. Kojetin D , Wang Y , Kamenecka T M , et al. Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB[J]. Acs Chemical Biology, 2011, 6(2):131-134.2. Dong D , Sun H , Wu Z , et al. A validated ultra-performance liquid chromatography-tandem mass spectrometry method to identify the pharmacokinetics of SR8278 in normal and streptozotocin-induced diabetic rats[J]. Journal of Chromatography B, 2016, 1020:142-147.
純度
99.44%
分子量
361.48
分子式
C18H19NO3S2
CAS No
1254944-66-5
存儲(chǔ)
0-4℃ for short term (days to weeks), or -20℃ for long term (months).
溶解度
DMSO: 10mg/ml(27.66mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
Note
For research use only .
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